Cancer Genomics and Metabolomics are two cutting-edge fields of research focused on understanding cancer biology at the molecular level. Both fields aim to provide insights into the mechanisms driving cancer development, progression, and treatment resistance, potentially leading to more precise and personalised cancer therapies.
Cancer genomics refers to the study of the genetic mutations, alterations, and variations that drive the initiation and progression of cancer. The genome consists of all the DNA in a cell, and changes in the genome (mutations) can lead to cancer. Cancer genomics is focused on identifying these mutations and understanding their roles.
Applications and Challenges
Personalized Cancer Treatment: Tailoring therapies based on a patient's genomic and metabolomic profile can improve treatment outcomes.
Biomarker Discovery: Genomic and metabolomic changes can serve as biomarkers for early detection, prognosis, and therapy response.
Resistance to Treatment: Genomic mutations and metabolic adaptations often lead to drug resistance. Understanding these mechanisms can guide the development of next-generation therapies.
Tracks:
Warburg Effect
Metabolic Reprogramming
Lipid Metabolism
Amino Acid Metabolism