Tailored solutions for complex diseases require systems that replicate patient-specific conditions. Disease modeling and personalized regenerative medicine combine 3D tissue models, patient-derived cells, and bioengineered platforms to predict treatment responses and design targeted therapies. By recreating pathological environments in vitro, researchers can evaluate drug efficacy and explore disease progression mechanisms. This approach reduces dependency on animal models and improves translational relevance. Integration with genomic data, artificial intelligence, and bioprinting allows for highly individualized therapeutic planning. Disease modeling and personalized regenerative medicine enhances precision medicine by aligning cellular behavior with specific genetic and environmental factors, making regenerative interventions more effective and patient-centered.