Hematopoietic malignancies, also known as blood cancers or hematologic cancers, are cancers that originate in the blood-forming tissues, such as the bone marrow or the cells of the immune system. These malignancies involve abnormal proliferation and functioning of the blood cells, leading to disruptions in normal blood cell production and immune function.
Bone Marrow Involvement: All hematopoietic malignancies involve abnormal functioning of the bone marrow, affecting blood cell production.
Genetic Mutations: Specific genetic mutations (e.g., BCR-ABL in CML, MYC translocation in Burkitt lymphoma) drive many hematopoietic malignancies.
Blood Abnormalities: Changes in blood cell counts, such as anaemia, leukocytosis (high white blood cell count), or thrombocytopenia (low platelet count), are common.
Organ Involvement: In addition to affecting the bone marrow and blood, these cancers can also infiltrate organs like the liver, spleen, and lymph nodes.
Immune System Dysregulation: These cancers often impair immune function, making patients more prone to infections
Tracks:
Leukaemia
Lymphoma
Multiple Myeloma