Strategies tailored to the unique architecture and physiology of each organ have redefined approaches to repair and replacement. Organ and tissue-specific regeneration focuses on restoring the form and function of organs such as the heart, liver, kidneys, and lungs using customized bioengineering techniques. With advances in vascularization, extracellular matrix mimicry, and bioprinting, scientists are constructing functional units that replicate native tissues. Decellularized scaffolds, region-specific growth factors, and patient-derived cells are enabling regeneration that aligns with biological cues unique to each system. Organ and Tissue-Specific Regeneration now plays a pivotal role in addressing complex pathologies and organ shortages, transforming transplantation and long-term recovery strategies.