By merging engineering principles with biology, synthetic biology & systems biology opens vast possibilities for designing new biological parts and reconstructing complex cellular networks. Synthetic biology is enabling the construction of artificial life forms, gene circuits, and programmable cells that serve targeted roles in diagnostics, therapy, and environmental sensing. Meanwhile, systems biology dissects intricate interconnections within living organisms using quantitative models and high-throughput data analysis. Together, these disciplines provide a holistic approach to understanding and redesigning biological functions. They support innovations in bioenergy, environmental engineering, and microbial production systems, often guided by AI and machine learning tools. The collaborative synergy of Synthetic Biology & Systems Biology lays the groundwork for predictive, customizable, and scalable biotechnological applications across multiple domains.