Radiation therapy remains a cornerstone in cancer treatment, offering precise tumor targeting while sparing healthy tissue. Radiation & Combined-Modality Therapy integrates radiation with other treatment strategies such as chemotherapy, immunotherapy, and targeted agents to enhance therapeutic efficacy and improve patient outcomes. Advances in imaging, dose planning, and delivery techniques, including intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), allow for highly precise interventions. By combining modalities, clinicians can exploit synergistic effects that improve tumor control, reduce recurrence risk, and minimize toxicity. Multidisciplinary collaboration among radiation oncologists, medical oncologists, surgeons, and supportive care teams ensures that treatment plans are tailored to individual patient needs.
The field of Radiation & Combined-Modality Therapy continues to evolve with the integration of novel systemic therapies and adaptive radiation strategies. Personalized treatment planning guided by molecular profiling and imaging biomarkers allows clinicians to optimize sequencing and dosing of therapies. Clinical trials investigating combination regimens, including radiosensitizers, immunotherapies, and targeted agents, are expanding options for patients with both localized and advanced disease. Supportive care and survivorship planning remain essential to managing side effects and maintaining quality of life. By combining advanced radiation techniques with systemic therapies and multidisciplinary care, radiation and combined-modality therapy provide a precision oncology approach that maximizes efficacy, improves long-term outcomes, and enhances overall patient well-being.