Non-covalent interactions, including hydrogen bonding, van der Waals forces, and π-π stacking, drive the self-assembly of complex molecular architectures with tailored properties. Advances in host-guest chemistry enable the design of molecular machines, drug delivery systems, and responsive materials. Supramolecular polymers and dynamic covalent networks exhibit adaptive behavior, finding applications in nanotechnology, soft materials, and biomedicine. Molecular recognition plays a crucial role in catalysis, sensing, and the development of synthetic receptors for targeted binding. The integration of supramolecular principles with nanotechnology enhances smart materials and stimuli-responsive systems. As research expands, supramolecular chemistry continues to shape the development of innovative materials, biomimetic systems, and functional nanostructures, paving the way for next-generation applications in medicine, energy, and environmental science.