Understanding and manipulating immune responses is critical for successful tissue regeneration. Immunotherapy & immune engineering explores how engineered immune cells and modulatory agents enhance tissue repair, prevent graft rejection, and support integration of bioengineered constructs. Researchers are developing immune-compatible scaffolds and combining stem cell technologies with immune checkpoint modulation to achieve lasting outcomes. Engineered T cells, regulatory macrophages, and cytokine delivery systems are now being applied to modulate inflammation and direct healing. The integration of immune engineering with regenerative platforms also contributes to resolving chronic inflammation and improving scaffold longevity. Immunotherapy & immune engineering continues to evolve into a cornerstone of precision regeneration, offering targeted solutions for both autoimmune and degenerative conditions.