Drug delivery strategies for gene therapies aim to efficiently transport genetic material into target cells, ensuring effective gene expression and therapeutic outcomes. Viral vectors like adeno-associated viruses (AAVs) or lentiviruses are commonly used for their ability to penetrate cell membranes and deliver genes to the nucleus. Non-viral methods include lipid nanoparticles, polymer-based carriers, and electroporation, offering safer alternatives with reduced immune responses. Innovations focus on enhancing delivery specificity, minimizing off-target effects, and optimizing dosing regimens to achieve sustained and therapeutic levels of gene expression. These strategies are crucial for advancing gene therapies across a range of genetic disorders, cancers, and other diseases.
Tracks:
Viral Vector Optimization
Non-Viral Delivery Systems
Targeting Strategies
In Vivo Imaging and Tracking